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Article

The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.

Cell - 14 Nov 1997

Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D

Abstract excerpt

We identified a complex in S. cerevisiae, the "exosome," consisting of the five essential proteins Rrp4p, Rrp41p, Rrp42p, Rrp43p, and Rrp44p (Dis3p). Remarkably, four of these proteins are homologous to characterized bacterial 3'-->5' exoribonucleases; Rrp44p is homologous to RNase II, while Rrp41p, Rrp42p, and Rrp43p are related to RNase PH. Recombinant Rrp4p, Rrp44p, and Rrp41p are 3'-->5' exoribonucleases in...

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PMID: 9390555
DOI: 10.1016/s0092-8674(00)80432-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.PMID 9390555Read ↗

A single subunit, Dis3, is essentially responsible for yeast exosome core activity.Semantic proximity Read ↗

RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities.Semantic proximity Read ↗

The CR3 motif of Rrp44p is important for interaction with the core exosome and exosome function.Semantic proximity Read ↗

The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome.Semantic proximity Read ↗

Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.Semantic proximity Read ↗

Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.Semantic proximity Read ↗

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.Semantic proximity Read ↗

Arabidopsis AtRRP44A is the functional homolog of Rrp44/Dis3, an exosome component, is essential for viability and is required for RNA processing and degradation.Semantic proximity Read ↗

Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs.Semantic proximity Read ↗

The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.Semantic proximity Read ↗

Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8 S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells.Semantic proximity Read ↗

Extensive degradation of RNA precursors by the exosome in wild-type cells.Semantic proximity Read ↗

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