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Article

Proteomic analysis of yeast mutant RNA exosome complexes.

Journal of proteome research - 6 Dec 2013

Lourenço Rogério F, Leme Adriana F P, Oliveira Carla C

Abstract excerpt

The yeast exosome is a conserved multiprotein complex essential for RNA processing and degradation. The complex is formed by a nine-subunit core that associates with two hydrolytic 3'-5' exoribonucleases. Although catalytically inert, the assembly of this nine-subunit core seems to be essential for the exosome activity, as mutations in regions that do not directly bind RNA or are not in the active sites of the...

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PMID: 24237138
DOI: 10.1021/pr400972x

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