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Article

The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro.

Nucleic acids research - 1 Apr 2013

Drazkowska Karolina, Tomecki Rafal, Stodus Krystian, Kowalska Katarzyna, Czarnocki-Cieciura Mariusz, Dziembowski Andrzej

Abstract excerpt

The RNA exosome is an essential ribonuclease complex involved in RNA processing and decay. It consists of a 9-subunit catalytically inert ring composed of six RNase PH-like proteins forming a central channel and three cap subunits with KH/S1 domains located at the top. The yeast exosome catalytic activity is supplied by the Dis3 (also known as Rrp44) protein, which has both endo- and exoribonucleolytic activities...

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Identifiers

PMID: 23404585
DOI: 10.1093/nar/gkt060
PMCID: PMC3616716

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