Article
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.
Blood - 16 Dec 2010
Jeannet Robin, Mastio Jérôme, Macias-Garcia Alejandra, Oravecz Attila, Ashworth Todd, Geimer Le Lay Anne-Solen, Jost Bernard, Le Gras Stéphanie, Ghysdael Jacques, Gridley Thomas, Honjo Tasuku, Radtke Freddy, Aster Jon C, Chan Susan, Kastner Philippe
Abstract excerpt
The Notch pathway is frequently activated in T-cell acute lymphoblastic leukemias (T-ALLs). Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 is expressed in all T-ALLs, but it is currently unclear how these receptors contribute to T-cell transformation in vivo. We investigated the role of Notch1 and Notch3 in T-ALL progression by a genetic approach, in mice bearing a...
Topics
- Animals
- Blotting, Northern
- Blotting, Western
- Cell Transformation, Neoplastic
- DNA Primers
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Ikaros Transcription Factor
- Immunoglobulin J Recombination Signal Sequence-Binding Protein