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MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategies

7 Jun 2021

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer that frequently occurs in children and adolescents, which results from the transformation of immature T-cell progenitors. Aberrant cell growth and proliferation of T-ALL lymphoblasts are sustained by activation of strong oncogenic drivers. Mounting evidence highlights the critical role of the NOTCH1-MYC highway toward the initiation...

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PMID: 35402840
DOI: 10.1097/bs9.0000000000000073

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