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Article

The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia.

Blood - 2 Mar 2017

Sanchez-Martin Marta, Ferrando Adolfo

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy that results from the transformation of immature T-cell progenitors. Aberrant cell growth and proliferation in T-ALL lymphoblasts are sustained by activation of strong oncogenic drivers promoting cell anabolism and cell cycle progression. Oncogenic NOTCH signaling, which is activated in more than 65% of T-ALL patients by...

Read the complete abstract on PubMed

Topics

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Share to NOTCH1 gene
Share to Cell Transformation, Neoplastic
Share to MYC gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-myc

Share to Receptor, Notch1

Source

Identifiers

PMID: 28115368
DOI: 10.1182/blood-2016-09-692582

Genes

NOTCH1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia.PMID 28115368Read ↗

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