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Article

Expression of EWS-ETS Fusions in NIH3T3 Cells Reveals Significant Differences to Ewing’s Sarcoma

17 Nov 2006

Abstract excerpt

Ewing's sarcomas contain specific chromosomal translocations that fuse EWS to ETS family members, including FLI, ERG, FEV, ETV1 and ETV4. Prior work has suggested that functional differences exist between some of these EWS-ETS fusions. However, as the cell of origin of Ewing's sarcoma is unknown, this prior work was conducted in NIH3T3 cells, which have not been validated as an appropriate model for the study of...

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Identifiers

PMID: 17172842
DOI: 10.4161/cc.5.23.3505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of EWS-ETS Fusions in NIH3T3 Cells Reveals Significant Differences to Ewing’s SarcomaPMID 17172842Read ↗

Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells.Semantic proximity Read ↗

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signatureSemantic proximity Read ↗

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.Semantic proximity Read ↗

Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.Semantic proximity Read ↗

Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.Semantic proximity Read ↗

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.Semantic proximity Read ↗

STAT3 is activated in a subset of the Ewing sarcoma family of tumoursSemantic proximity Read ↗

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts.Semantic proximity Read ↗

Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?Semantic proximity Read ↗

PIM3 Proto-Oncogene Kinase Is a Common Transcriptional Target of Divergent EWS/ETS OncoproteinsSemantic proximity Read ↗

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