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Article

Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?

1 Apr 1996

Abstract excerpt

PURPOSE: Because of the high heterogeneity of EWS gene fusions with FLI1 and ERG genes due to variable chromosomal breakpoint locations in Ewing tumors (ET) (14 different chimeric transcripts identified so far), we evaluated the clinical impact of the expression of diverse fusion transcripts in ET patients. PATIENTS AND METHODS: In a European multicenter study, 147 ET were analyzed by reverse-transcriptase...

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PMID: 8648380
DOI: 10.1200/jco.1996.14.4.1245

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