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Article

Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells.

Oncogene - 30 Sept 1999

Thompson A D, Teitell M A, Arvand A, Denny C T

Abstract excerpt

Ewing's sarcomas express chimeric transcription factors resulting from a fusion of the amino terminus of the EWS gene to the carboxyl terminus of one of five ETS proteins. While the majority of tumors express EWS/FLI1 fusions, some Ewing's tumors contain variant chimeras such as EWS/ETV1 that have divergent ETS DNA-binding domains. In spite of their structural differences, both EWS/ETS fusions up regulate EAT-2,...

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Topics

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Share to 3T3 Cells
Share to Bone Neoplasms
Share to Mice, SCID

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Transplantation

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to Sarcoma, Ewing

Source

Identifiers

PMID: 10523827
DOI: 10.1038/sj.onc.1202928

Genes

FLI1
ETV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells.PMID 10523827Read ↗

Expression of EWS-ETS Fusions in NIH3T3 Cells Reveals Significant Differences to Ewing’s SarcomaSemantic proximity Read ↗

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenicSemantic proximity Read ↗

Caveolin-1 ( CAV1 ) Is a Target of EWS/FLI-1 and a Key Determinant of the Oncogenic Phenotype and Tumorigenicity of Ewing's Sarcoma CellsSemantic proximity Read ↗

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.Semantic proximity Read ↗

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.Semantic proximity Read ↗

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.Semantic proximity Read ↗

Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcomaSemantic proximity Read ↗

An association between viral genes and human oncogenic alterations: the adenovirus E1A induces the Ewing tumor fusion transcript EWS-FLI1.Semantic proximity Read ↗

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.Semantic proximity Read ↗

A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesisSemantic proximity Read ↗

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion proteinSemantic proximity Read ↗

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