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Article

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

15 Jan 2008

Abstract excerpt

Ewing's sarcomas are characterized by recurrent chromosomal translocations expressing EWS-ETS fusion proteins, the most common of which is EWS-FLI.(1-5) EWS-FLI is an oncogenic transcription factor that regulates genes involved in tumorigenesis.(6,7) Because the Ewing's sarcoma cell of origin remains unknown, a variety of model systems have been developed to study EWS-FLI fusions,(8-14) and multiple microarray...

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PMID: 18256529
DOI: 10.4161/cc.7.2.5229

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A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signaturePMID 18256529Read ↗

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