Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.

doi:10.1200/JCO.2009.23.3585

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Article

Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Apr 2010

Le Deley Marie-Cecile, Delattre Olivier, Schaefer Karl-Ludwig, Burchill Sue A, Koehler Gabriele, Hogendoorn Pancras C W, Lion Thomas, Poremba Christopher, Marandet Julien, Ballet Stelly, Pierron Gaelle, Brownhill Samantha C, Nesslböck Michaela, Ranft Andreas, Dirksen Uta, Oberlin Odile, Lewis Ian J, Craft Alan W, Jürgens Heribert, Kovar Heinrich

Abstract excerpt

PURPOSE EWS-ETS fusion genes are the driving force in Ewing's sarcoma pathogenesis. Because of the variable breakpoint locations in the involved genes, there is heterogeneity in fusion RNA and protein architecture. Since previous retrospective studies suggested prognostic differences among patien...

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Identifiers

PMID: 20308673
DOI: 10.1200/JCO.2009.23.3585

Genes

FLI1
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20308673-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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