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Article

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.

Oncogene - 22 May 2008

Zwerner J P, Joo J, Warner K L, Christensen L, Hu-Lieskovan S, Triche T J, May W A

Abstract excerpt

Ewing family tumors (EFT), classically Ewing's sarcoma and peripheral primitive neuroectodermal tumor, share a common class of tumor-specific fusion genes thought to be key mediators of tumor biology. Here we demonstrate that the most common Ewing's fusion, EWS/FLI1, produces transcriptional upregulation of GLI1 and its direct transcriptional target PATCHED1 in a model transformation system. This deregulation of...

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Share to Bone Neoplasms
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Share to Kruppel-Like Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NIH 3T3 Cells

Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to Sarcoma, Ewing

Share to Zinc Finger Protein GLI1

Source

Identifiers

PMID: 18084326
DOI: 10.1038/sj.onc.1210991

Genes

GLI1
FLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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The EWS/FLI1 oncogenic transcription factor deregulates GLI1.PMID 18084326Read ↗

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FOXM1 Is an Oncogenic Mediator in Ewing SarcomaSemantic proximity Read ↗

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