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Article

Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2006

Mahoney Zhen X, Sammut Bénédicte, Xavier Ramnik J, Cunningham Jeanette, Go Gloriosa, Brim Karry L, Stappenbeck Thaddeus S, Miner Jeffrey H, Swat Wojciech

Abstract excerpt

Discs-large homolog 1 (DLGH1) is a mouse ortholog of the Drosophila discs-large (DLG) tumor suppressor protein, a founding member of the PDZ and MAGUK protein families. DLG proteins play important roles in regulating cell proliferation, epithelial cell polarity, and synapse formation and function. Here, we generated a null allele of Dlgh1 and studied its role in urogenital development. Dlgh1(-/-) mice developed...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Guanylate Kinases

Share to Mice, Knockout

Share to Muscle, Smooth

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Source

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Identifiers

PMID: 17172448
DOI: 10.1073/pnas.0609326103
PMCID: PMC1750896

Genes

DLG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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