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Article

Gen1 mutation caused kidney hypoplasia and defective ureter-bladder connections in mice.

International journal of biological sciences - 1 Jan 2020

Wang Xiaowen, Wang Herui, Liu Jiaojiao, Gong Yinv, Zhang Chi, Fang Francia, Li Aiguo, Wu Xiaohui, Shen Qian, Xu Hong

Abstract excerpt

Limited genetic factors were uncovered for the development of congenital anomalies of the kidney and urinary tract (CAKUT). We previously reported that a Holliday junction resolvase Gen1 was essential for early metanephric development in mice. This comprehensive follow-up study focused on the roles of Gen1 in late metanephric development. We found that Gen1 mutation impaired the late development of both kidney...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32226308
DOI: 10.7150/ijbs.42855
PMCID: PMC7097914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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