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Article

The signaling pathways of LMX1B and its role in glomerulosclerosis

9 Oct 2012

Abstract excerpt

LMX1B, a developmental LIM-homeodomain transcription factor, is widely expressed in vertebrate embryos, and it takes part in the development of diverse structures such as limbs, kidneys, eyes, brains, etc. LMX1B contributes to transcriptional regulation of glomerular basement membrane (GBM) collagen expression by podocytes. The normal function of podocytes and the normal morphology of GBM are very important to...

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PMID: 23046462
DOI: 10.3109/10799893.2012.727832

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