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Article

Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice

8 Oct 2007

Abstract excerpt

Kidney development and physiology require polarization of epithelia that line renal tubules. Genetic studies show that polarization of invertebrate epithelia requires the crumbs, partition-defective-3, and discs large complexes. These evolutionarily conserved protein complexes occur in mammalian kidney; however, their role in renal development remains poorly defined. Here, we find that mice lacking the small PDZ...

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PMID: 17923534
DOI: 10.1083/jcb.200702054

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