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Article

Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.

BMC biology - 10 Apr 2007

Schwab Kristopher R, Patterson Larry T, Hartman Heather A, Song Ni, Lang Richard A, Lin Xinhua, Potter S Steven

Abstract excerpt

BACKGROUND: The pygopus gene of Drosophila encodes an essential component of the Armadillo (beta-catenin) transcription factor complex of canonical Wnt signaling. To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2. RESULTS: Each mutation deleted >80% of the coding sequence, including the...

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Identifiers

PMID: 17425782
DOI: 10.1186/1741-7007-5-15
PMCID: PMC1858683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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