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Article

Requirement of DLG1 for cardiovascular development and tissue elongation during cochlear, enteric, and skeletal development: possible role in convergent extension.

PloS one - 1 Jan 2015

Iizuka-Kogo Akiko, Senda Takao, Akiyama Tetsu, Shimomura Atsushi, Nomura Ryuji, Hasegawa Yoshimi, Yamamura Ken-Ichi, Kogo Hiroshi, Sawai Nobuhiko, Matsuzaki Toshiyuki

Abstract excerpt

The Dlg1 gene encodes a member of the MAGUK protein family involved in the polarization of epithelial cells. Null mutant mice for the Dlg1 gene (Dlg1-/- mice) exhibit respiratory failure and cyanosis, and die soon after birth. However, the cause of this neonatal lethality has not been determined. In the present study, we further examined Dlg1-/- mice and found severe defects in the cardiovascular system,...

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Source

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Identifiers

PMID: 25860837
DOI: 10.1371/journal.pone.0123965
PMCID: PMC4393223

Genes

DLG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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