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Article

Phosphorylation and regulation of beta-catenin by casein kinase I epsilon.

Journal of biochemistry - 1 Nov 2002

Sakanaka Chie

Abstract excerpt

beta-Catenin transduces cytosolic signals to the nucleus in the Wnt pathway. The Wnt ligand stabilizes cytosolic beta-catenin protein, preventing its phosphorylation by inhibiting glycogen synthase kinase 3 (GSK3). Serine-33 and -37 of beta-catenin are GSK3 phosphorylation sites that serve as recognition sites for the beta-TRCP-ubiquitin ligase complex, which ultimately triggers beta-catenin degradation....

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Identifiers

PMID: 12417018
DOI: 10.1093/oxfordjournals.jbchem.a003276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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