Article
Dominant-negative p53 can restore tumorigenicity of L-929 cells in immunocompetent mice.
International journal of cancer - 15 Nov 1995
Appleman L J, Frey A B
Abstract excerpt
To study the effect of a transforming allele of the tumor suppressor p53 upon the anti-tumor immune response, antigenic L-929 cells were transfected with the dominant-negative valine135 mutant of murine p53. Several p53val135-expressing transfectants formed non-regressing tumors in immunocompeten...
Topics
- Alleles
- Animals
- Cell Transformation, Neoplastic
- Genes, Dominant
- Genes, p53
- Histocompatibility Antigens Class I
- Immunocompetence
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Nude
- Skin Neoplasms
- T-Lymphocytes, Cytotoxic
- Transfection
- Transforming Growth Factor beta
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha