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Some cellular and molecular characteristics of high and low tumorigenicity variants of polyoma-virus transformed cells.

Molecular immunology - 1 Dec 1990

Berko-Flint Y, Fridman W H, Grossman-Atlas E, Kimchi N, Ben-Baruch A L, Moss S, Teillaud J L, Witz I P, Ran M

Abstract excerpt

We analyzed several cellular and molecular properties of BALB/c 3T3 cellular clones transformed in vitro with polyoma virus and exhibiting a high or low tumorigenicity phenotype. We also analyzed the same clones after a single in vivo passage in syngeneic mice. This passage invariably induced and/or selected variants exhibiting a very high tumorigenicity phenotype. BALB/c mice bearing tumors induced by the...

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PMID: 2177146
DOI: 10.1016/0161-5890(90)90025-u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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