Article
Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein.
Cancer gene therapy - 1 Jan 2000
Harris M P, Sutjipto S, Wills K N, Hancock W, Cornell D, Johnson D E, Gregory R J, Shepard H M, Maneval D C
Abstract excerpt
Human malignancies are often characterized by mutations of the p53 tumor suppressor gene. In a large proportion of cases, the mutation results in production of an altered protein that can bind and inactivate the wild-type gene product. This "dominant-negative" activity of mutant p53 molecules may...
Topics
- Adenoviridae
- Animals
- Cell Division
- Colorectal Neoplasms
- Female
- Gene Transfer Techniques
- Genes, p53
- Genetic Therapy
- Genetic Vectors
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mutation
- Recombination, Genetic
- Survival Rate
- Transduction, Genetic
- Tumor Cells, Cultured