p53 activity is essential for normal development in Xenopus.

doi:10.1016/s0960-9822(06)00333-2

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Article

p53 activity is essential for normal development in Xenopus.

Current biology : CB - 1 Oct 1997

Wallingford J B, Seufert D W, Virta V C, Vize P D

Abstract excerpt

BACKGROUND: The tumor suppressor p53 plays a key role in regulating the cell cycle and apoptosis in differentiated cells. Mutant mice lacking functional p53 develop normally but die from multiple neoplasms shortly after birth. There have been hints that p53 is involved in morphogenesis, but given...

Topics

Animals
Blastocyst
Cell Differentiation
Humans
Mutation
Neoplasm Proteins
Neoplasms
Nuclear Proteins
Phenotype
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Recombinant Fusion Proteins
Tumor Suppressor Protein p53
Xenopus Proteins
Xenopus laevis

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