Article
p53 activity is essential for normal development in Xenopus.
Current biology : CB - 1 Oct 1997
Wallingford J B, Seufert D W, Virta V C, Vize P D
Abstract excerpt
BACKGROUND: The tumor suppressor p53 plays a key role in regulating the cell cycle and apoptosis in differentiated cells. Mutant mice lacking functional p53 develop normally but die from multiple neoplasms shortly after birth. There have been hints that p53 is involved in morphogenesis, but given the relatively normal development of p53 null mice, the significance of these data has been difficult to evaluate. To...
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