Article
Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development.
Cancer research - 15 Jul 1993
Jerry D J, Ozbun M A, Kittrell F S, Lane D P, Medina D, Butel J S
Abstract excerpt
Preneoplastic lesions in the mammary gland represent a population of cells at increased risk of progression to tumors. Because p53 is the most commonly mutated gene in human breast cancer, we sought to determine whether mutations in p53 were present in preneoplastic lesions or were acquired during progression to overt tumors. In the mouse mammary gland, hyperplastic alveolar nodules (HAN) are the most common...
Topics
- Animals
- Base Sequence
- Cell Nucleus
- Female
- Genes, p53
- Mammary Neoplasms, Animal
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Precancerous Conditions
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53