Article
Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1997
Shick L, Carman J H, Choi J K, Somasundaram K, Burrell M, Hill D E, Zeng Y X, Wang Y, Wiman K G, Salhany K, Kadesch T R, Monroe J G, Donehower L A, el-Deiry W S
Abstract excerpt
Recent studies have hinted that there may be a relationship between p53 and the immune response. In preliminary experiments, we found significantly decreased levels of immunoglobulin deposition in 13 of 16 p53-null tumors compared with 2 of 17 tumors derived from p53 +/- mice. We further explored the effect of p53 on B-cell development and function. p53-null mice contained more splenic white pulp and more...
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