Article
Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1997
Shick L, Carman J H, Choi J K, Somasundaram K, Burrell M, Hill D E, Zeng Y X, Wang Y, Wiman K G, Salhany K, Kadesch T R, Monroe J G, Donehower L A, el-Deiry W S
Abstract excerpt
Recent studies have hinted that there may be a relationship between p53 and the immune response. In preliminary experiments, we found significantly decreased levels of immunoglobulin deposition in 13 of 16 p53-null tumors compared with 2 of 17 tumors derived from p53 +/- mice. We further explored...
Topics
- Animals
- Antigens, Neoplasm
- B-Lymphocytes
- Binding Sites
- Blotting, Western
- Bone Marrow
- Cell Differentiation
- DNA-Binding Proteins
- Female
- Genes, Regulator
- Genes, p53
- Genotype
- Glioblastoma
- Immunoglobulins