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Article

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.

Molecular immunology - 1 Nov 2008

Zan Hong, Casali Paolo

Abstract excerpt

Class switch DNA recombination (CSR) substitutes an immunoglobulin (Ig) constant heavy chain (C(H)) region with a different C(H) region, thereby endowing an antibody with different biological effector functions. CSR requires activation-induced cytidine deaminase (AID) and occurrence of double-strand DNA breaks (DSBs) in S regions of upstream and downstream C(H) region genes. DSBs are critical for CSR and would be...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Breaks, Double-Stranded

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Source

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Identifiers

PMID: 18760480
DOI: 10.1016/j.molimm.2008.07.003
PMCID: PMC2975703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.PMID 18760480Read ↗

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Semantic proximity Read ↗

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.Semantic proximity Read ↗

AID Binds Cooperatively with UNG and Msh2-Msh6 to Ig Switch Regions Dependent upon the AID C TerminusSemantic proximity Read ↗

Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.Semantic proximity Read ↗

DNA Double-Strand BreaksSemantic proximity Read ↗

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombinationSemantic proximity Read ↗

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.Semantic proximity Read ↗

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.Semantic proximity Read ↗

The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombinationSemantic proximity Read ↗

APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.Semantic proximity Read ↗

AID-initiated DNA lesions are differentially processed in distinct B cell populations.Semantic proximity Read ↗

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