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Article

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.

Molecular immunology - 1 Jan 2011

Zan Hong, Zhang Jinsong, Al-Qahtani Ahmed, Pone Egest J, White Clayton A, Lee Derrik, Yel Leman, Mai Thach, Casali Paolo

Abstract excerpt

Immunoglobulin (Ig) class switch DNA recombination (CSR) is the crucial mechanism diversifying the biological effector functions of antibodies. Generation of double-strand DNA breaks (DSBs), particularly staggered DSBs, in switch (S) regions of the upstream and downstream CH genes involved in the specific recombination process is an absolute requirement for CSR. Staggered DSBs would be generated through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21111482
DOI: 10.1016/j.molimm.2010.10.023
PMCID: PMC3412130

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