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Article

Cross-regulation of VPAC(2) receptor desensitization by M(3) receptors via PKC-mediated phosphorylation of RKIP and inhibition of GRK2.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2007

Huang Jiean, Mahavadi Sunila, Sriwai Wimolpak, Grider John R, Murthy Karnam S

Abstract excerpt

In gastrointestinal smooth muscle cells, VPAC(2) receptor desensitization is exclusively mediated by G protein-coupled receptor kinase 2 (GRK2). The present study examined the mechanisms by which acetylcholine (ACh) acting via M(3) receptors regulates GRK2-mediated VPAC(2) receptor desensitization in gastric smooth muscle cells. Vasoactive intestinal peptide induced VPAC(2) receptor phosphorylation,...

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Source

Identifiers

PMID: 17170028
DOI: 10.1152/ajpgi.00326.2006

Genes

GRK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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