Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling.

The Journal of biological chemistry - 29 Jul 2005

Langlet Christelle, Langer Ingrid, Vertongen Pascale, Gaspard Nathalie, Vanderwinden Jean-Marie, Robberecht Patrick

Abstract excerpt

When exposed to vasoactive intestinal peptide (VIP), the human wild type VPAC1 receptor expressed in Chinese hamster ovary (CHO) cells is rapidly phosphorylated, desensitized, and internalized in the endosomal compartment and is not re-expressed at the cell membrane within 2 h after agonist removal. The aims of the present work were first to correlate receptor phosphorylation level to internalization and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Adenylyl Cyclases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CHO Cells

Share to Endosomes

Share to Immunoprecipitation

Share to Microscopy, Confocal

Share to Serine

Share to Vasoactive Intestinal Peptide

Source

Identifiers

PMID: 15932876
DOI: 10.1074/jbc.M500449200

Genes

VIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling.PMID 15932876Read ↗

Mutation of the phosphorylatable residue Thr429 in Glu of the human VPAC1 led to a constitutively desensitized receptor.Semantic proximity Read ↗

Phosphorylation and recycling kinetics of G protein-coupled receptors.Semantic proximity Read ↗

Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor.Semantic proximity Read ↗

Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail.Semantic proximity Read ↗

Asn229 in the third helix of VPAC1 receptor is essential for receptor activation but not for receptor phosphorylation and internalization: comparison with Asn216 in VPAC2 receptor.Semantic proximity Read ↗

Identification of an essential amino acid motif within the C terminus of the pituitary adenylate cyclase-activating polypeptide type I receptor that is critical for signal transduction but not for receptor internalization.Semantic proximity Read ↗

Phosphorylation of the angiotensin II (AT1A) receptor carboxyl terminus: a role in receptor endocytosis.Semantic proximity Read ↗

The human vasoactive intestinal Peptide/Pituitary adenylate cyclase activating peptide receptor 1 (VPAC1): constitutive activation by mutations at threonine 343.Semantic proximity Read ↗

Finding functional gaps: integrative analysis of VPAC1- and VPAC2-mediated signalling pathways in human lymphocytesSemantic proximity Read ↗

Roles of the phosphorylation sites of distinct α1A-adrenergic receptor domains.Semantic proximity Read ↗

Mutations in the carboxy-terminus of the third intracellular loop of the human recombinant VPAC1 receptor impair VIP-stimulated [Ca2+]i increase but not adenylate cyclase stimulation.Semantic proximity Read ↗

Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.