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Article

Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor.

Journal of molecular endocrinology - 1 Apr 2005

Langer Ingrid, Langlet Christelle, Robberecht Patrick

Abstract excerpt

The VPAC(2) receptor, as all members of the G-protein-coupled receptor (GPCR)-B family, has two highly conserved motifs in the third intracellular (IC(3)) loop: a lysine and a leucine located at the amino-terminus and two basic residues separated by a leucine and an alanine at the carboxyl-terminus. This study evaluates the involvement of those conserved amino acid sequences in VPAC(2) signal transduction and...

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Source

Identifiers

PMID: 15821106
DOI: 10.1677/jme.1.01717

Genes

VIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor.PMID 15821106Read ↗

Mutations in the carboxy-terminus of the third intracellular loop of the human recombinant VPAC1 receptor impair VIP-stimulated [Ca2+]i increase but not adenylate cyclase stimulation.Semantic proximity Read ↗

Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.Semantic proximity Read ↗

Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC(2): role of basic residues in the second transmembrane helix.Semantic proximity Read ↗

Asn229 in the third helix of VPAC1 receptor is essential for receptor activation but not for receptor phosphorylation and internalization: comparison with Asn216 in VPAC2 receptor.Semantic proximity Read ↗

Mutation of the phosphorylatable residue Thr429 in Glu of the human VPAC1 led to a constitutively desensitized receptor.Semantic proximity Read ↗

Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling.Semantic proximity Read ↗

The human vasoactive intestinal Peptide/Pituitary adenylate cyclase activating peptide receptor 1 (VPAC1): constitutive activation by mutations at threonine 343.Semantic proximity Read ↗

Two tyrosine residues in the first transmembrane helix of the human vasoactive intestinal peptide receptors play a role in supporting the active conformation.Semantic proximity Read ↗

A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function.Semantic proximity Read ↗

Identification of an essential amino acid motif within the C terminus of the pituitary adenylate cyclase-activating polypeptide type I receptor that is critical for signal transduction but not for receptor internalization.Semantic proximity Read ↗

Identification and characterization of five-transmembrane isoforms of human vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors.Semantic proximity Read ↗

Roles of the phosphorylation sites of distinct α1A-adrenergic receptor domains.Semantic proximity Read ↗

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