Article
Mitochondrial DNA mutations in pancreatic cancer.
International journal of gastrointestinal cancer - 1 Jan 2006
Kassauei Keyanoosh, Habbe Nils, Mullendore Michael E, Karikari Collins A, Maitra Anirban, Feldmann Georg
Abstract excerpt
BACKGROUND: Somatic mutations of mitochondrial DNA (mtDNA) are increasingly being recognized in many human cancers, but automated sequencing of 16.5 kb of DNA poses an onerous task. We have recently described an oligonucleotide microarray (MitoChip) for rapid and accurate sequencing of the entire mitochondrial genome (Zhou et al., J Mol Diagnostics, 8: 9_14, 2006), greatly facilitating the analysis of mtDNA...
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