Article
Oxidative DNA damage drives carcinogenesis in MUTYH-associated-polyposis by specific mutations of mitochondrial and MAPK genes.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2013
Venesio Tiziana, Balsamo Antonella, Errichiello Edoardo, Ranzani Guglielmina N, Risio Mauro
Abstract excerpt
MUTYH is a DNA-base-excision-repair gene implicated in the activation of nuclear and mitochondrial cell-death pathways. MUTYH germline mutations cause an inherited polyposis, MUTYH-associated-polyposis, characterized by multiple adenomas and increased susceptibility to colorectal cancer. Since this carcinogenesis remains partially unknown, we searched for nuclear and mitochondrial gene alterations that may drive...
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