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Article

Solution-phase DNA mutation scanning and SNP genotyping by nanoliter melting analysis.

Biomedical microdevices - 1 Apr 2007

Sundberg Scott O, Wittwer Carl T, Greer Jenny, Pryor Robert J, Elenitoba-Johnson Oluwole, Gale Bruce K

Abstract excerpt

Solution-phase, DNA melting analysis for heterozygote scanning and single nucleotide polymorphism (SNP) genotyping was performed in 10 nl volumes on a custom microchip. Human genomic DNA was PCR amplified in the presence of the saturating fluorescent dye, LCGreen Plus, and placed within microfluidic channels that were created between two glass slides. The microchip was heated at 0.1 degrees C/s with a Peltier...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

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Share to Oligonucleotide Array Sequence Analysis

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Identifiers

PMID: 17165128
DOI: 10.1007/s10544-006-9017-3

Genes

ATM
CFTR
HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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