Article
Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke.
American heart journal - 1 Dec 2006
Ding Jingzhong, Nicklas Barbara J, Fallin Margaret D, de Rekeneire Nathalie, Kritchevsky Stephen B, Pahor Marco, Rodondi Nicolas, Li Rongling, Zmuda Joseph M, Harris Tamara B
Abstract excerpt
BACKGROUND: The 4G allele in the promoter region of the plasminogen activator inhibitor type 1 (PAI-1) gene is associated with higher plasma PAI-1 levels and activity, but its association with cardiovascular diseases is unclear. We investigated the association of polymorphisms and common haplotypes of the PAI-1 gene with plasma PAI-1 levels, as well as the risk of myocardial infarction and stroke. METHODS AND...
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