Article
Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2007
Morange P E, Saut N, Alessi M C, Yudkin J S, Margaglione M, Di Minno G, Hamsten A, Humphries S E, Tregouet D A, Juhan-Vague I
Abstract excerpt
OBJECTIVE: The purpose of this study was to investigate the effects of plasminogen activator inhibitor-1 (PAI-1) gene (SERPINE1) single nucleotide polymorphisms (SNPs) on the risk of myocardial infarction (MI), on PAI-1 levels, and factors related to the metabolic syndrome. METHODS AND RESULTS: Eleven SNPs capturing the common genetic variation of the SERPINE1 gene were genotyped in the HIFMECH study. In the 510...
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