Article
Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels.
Circulation - 20 Sept 2005
Kathiresan Sekar, Gabriel Stacey B, Yang Qiong, Lochner Amy L, Larson Martin G, Levy Daniel, Tofler Geoffrey H, Hirschhorn Joel N, O'Donnell Christopher J
Abstract excerpt
BACKGROUND: Using a linkage disequilibrium (LD)-based approach, we sought to comprehensively define common genetic variation at the plasminogen activator inhibitor-1 (PAI-1) locus and relate common single nucleotide polymorphisms (SNPs) and haplotypes to plasma PAI-1 levels. METHODS AND RESULTS: In reference pedigrees, we defined LD structure across a 50-kb genomic segment spanning the PAI-1 locus via a dense SNP...
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