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Article

4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly.

Stroke - 1 Dec 2003

Hoekstra Tiny, Geleijnse Johanna M, Kluft Cornelis, Giltay Erik J, Kok Frans J, Schouten Evert G

Abstract excerpt

BACKGROUND AND PURPOSE: Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of fibrinolysis, and high levels may increase the risk of cardiovascular disease. The 4G/5G polymorphism affects PAI-1 gene transcription with lower levels of plasma PAI-1 in the presence of the 5G allele. We investigated whether plasma PAI-1 and 4G/5G genotype would predict the occurrence of cardiovascular events at old...

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Identifiers

PMID: 14605330
DOI: 10.1161/01.STR.0000098004.26252.EB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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