Article
Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2006
Su Shaoyong, Chen Shufeng, Zhao Jiangong, Huang Jianfeng, Wang Xiaoling, Chen Runsheng, Gu Dongfeng
Abstract excerpt
OBJECTIVE: To explore the effect of plasminogen activator inhibitor-1 (PAI-1) gene variations on the risk of coronary heart disease (CHD) in Chinese Han population. METHODS AND RESULTS: We screened all exons and the promoter region of PAI-1 gene in 48 patients and identified 17 polymorphisms. Five tagging single nucleotide polymorphisms were selected and genotyped in 816 patients with CHD and 937 controls. In the...
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