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Article

Plasminogen activator inhibitor 4G polymorphism is associated with decreased risk of cerebrovascular mortality in older women.

Circulation - 1 Jan 2000

Roest M, van der Schouw Y T, Banga J D, Tempelman M J, de Groot P G, Sixma J J, Grobbee D E

Abstract excerpt

BACKGROUND: A common 4G allele of a 4G/5G polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with increased transcription of the PAI-1 protein, which may lead to decreased fibrinolysis. It has therefore been proposed as a candidate risk factor for myocardial infarction or stroke. METHODS AND RESULTS: We studied the relationship between PAI-1 4G/5G genotype and...

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Source

Identifiers

PMID: 10618306
DOI: 10.1161/01.cir.101.1.67

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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