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Article

Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995

Eriksson P, Kallin B, van 't Hooft F M, Båvenholm P, Hamsten A

Abstract excerpt

Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 promoter is associated with higher plasma PAI-1 activity. The prevalence of the 4G allele is...

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Identifiers

PMID: 7892190
DOI: 10.1073/pnas.92.6.1851
PMCID: PMC42380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.PMID 7892190Read ↗

Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarction.Semantic proximity Read ↗

The PAI-1 Gene Locus 4G/5G Polymorphism Is Associated With a Family History of Coronary Artery DiseaseSemantic proximity Read ↗

Association of the plasminogen activator inhibitor-1 gene 4G/5G polymorphism with ST elevation acute myocardial infarction in young patients.Semantic proximity Read ↗

The 4G/5G polymorphism of PAI-1 promoter gene and the risk of myocardial infarction: a meta-analysis.Semantic proximity Read ↗

Association of PAI-1 4G/5G and -844G/A gene polymorphisms and changes in PAI-1/tissue plasminogen activator levels in myocardial infarction: a case-control study.Semantic proximity Read ↗

A novel polymorphism in the PAI-1 gene promoter enhances gene expression. A novel pro-thrombotic risk factor?Semantic proximity Read ↗

4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly.Semantic proximity Read ↗

Plasminogen Activator Inhibitor-1 Promoter 4G/5G Genotype and Plasma Levels in Relation to a History of Myocardial Infarction in Patients Characterized by Coronary AngiographySemantic proximity Read ↗

Plasminogen activator inhibitor-1 (PAI-1) promoter 4G/5G genotype and increased PAI-1 circulating levels in postmenopausal women with coronary artery disease.Semantic proximity Read ↗

An effect of the PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke.Semantic proximity Read ↗

Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke.Semantic proximity Read ↗

Plasminogen activator inhibitor 4G polymorphism is associated with decreased risk of cerebrovascular mortality in older women.Semantic proximity Read ↗

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