Article
Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995
Eriksson P, Kallin B, van 't Hooft F M, Båvenholm P, Hamsten A
Abstract excerpt
Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymor...
Topics
- Adult
- Alleles
- Base Sequence
- Binding Sites
- Carcinoma, Hepatocellular
- Cell Line
- Cell Nucleus
- DNA-Binding Proteins
- Deoxyribonuclease I
- Gene Expression
- Genotype
- Humans
- Liver Neoplasms
- Male
- Methylation