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Article

An effect of the PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2006

Boncoraglio Giorgio B, Bodini Antonella, Brambilla Carla, Carriero Maria Rita, Ciusani Emilio, Parati Eugenio A

Abstract excerpt

BACKGROUND AND PURPOSE: The gene-encoding plasminogen activator inhibitor type 1 (PAI-1) has a common 4G/5G 'functional' polymorphism, and people homozygous for the 4G allele have higher PAI-1 plasma concentrations. The 4G/4G genotype is associated with increased risk of myocardial infarction but paradoxically protects against stroke. We hypothesized that this paradox may be explained via an effect of the PAI-1...

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Identifiers

PMID: 16735791
DOI: 10.1159/000093604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An effect of the PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke.PMID 16735791Read ↗

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