Article
Evaluation of polymorphism, hypermethylation and expression pattern of CTLA4 gene in a sample of Iranian patients with schizophrenia.
Molecular biology reports - 1 Aug 2013
Kordi-Tamandani Dor Mohammad, Vaziri Shahram, Dahmardeh Nahid, Torkamanzehi Adam
Abstract excerpt
The cytotoxic T lymphocyte-associated antigen 4 gene (CTLA4) has a crucial role in regulation of T cell proliferation and mediates T cell apoptosis by encoding the T cell receptor. Schizophrenia (SCZ) patients often have abnormalities in terms of the function and development of the immune system. The aim of the present study was to investigate promoter variation and expression profile of the CTLA4 gene in...
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