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Article

KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.

The Journal of biological chemistry - 9 Feb 2007

Qi Wei, Yu Hongtao

Abstract excerpt

The spindle checkpoint is a cell cycle surveillance mechanism that ensures the fidelity of chromosome segregation during mitosis and meiosis. Bub1 is a protein serine-threonine kinase that plays multiple roles in chromosome segregation and the spindle checkpoint. In response to misaligned chromosomes, Bub1 directly inhibits the ubiquitin ligase activity of the anaphase-promoting complex or cyclosome (APC/C) by...

Topics

Anaphase
Anaphase-Promoting Complex-Cyclosome
Antigens, CD
Cadherins
G1 Phase
HCT116 Cells
HeLa Cells
Humans
Mitosis
Mutation
Protein Kinase Inhibitors
Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Substrate Specificity

Ubiquitin-Protein Ligase Complexes

Ubiquitins

Source

Identifiers

PMID: 17158872
DOI: 10.1074/jbc.M609376200

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17158872-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.PMID 17158872Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.Semantic proximity Read ↗

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Semantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase.Semantic proximity Read ↗

Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Semantic proximity Read ↗

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.Semantic proximity Read ↗

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Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

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