Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.

The Journal of biological chemistry - 9 Feb 2007

Qi Wei, Yu Hongtao

Abstract excerpt

The spindle checkpoint is a cell cycle surveillance mechanism that ensures the fidelity of chromosome segregation during mitosis and meiosis. Bub1 is a protein serine-threonine kinase that plays multiple roles in chromosome segregation and the spindle checkpoint. In response to misaligned chromosomes, Bub1 directly inhibits the ubiquitin ligase activity of the anaphase-promoting complex or cyclosome (APC/C) by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to APC gene
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitosis

Share to Mutation

Share to Protein Kinases

Share to Protein Serine-Threonine Kinases

Share to Substrate Specificity

Source

Identifiers

PMID: 17158872
DOI: 10.1074/jbc.M609376200

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.PMID 17158872Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.Semantic proximity Read ↗

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Semantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase.Semantic proximity Read ↗

Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Semantic proximity Read ↗

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.Semantic proximity Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.