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Article

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.

The EMBO journal - 17 May 1999

Alexandru G, Zachariae W, Schleiffer A, Nasmyth K

Abstract excerpt

In yeast, anaphase entry depends on Pds1 proteolysis, while chromosome re-duplication in the subsequent S-phase involves degradation of mitotic cyclins such as Clb2. Sequential proteolysis of Pds1 and mitotic cyclins is mediated by the anaphase-promoting complex (APC). Lagging chromosomes or spindle damage are detected by surveillance mechanisms (checkpoints) which block anaphase onset, cytokinesis and DNA...

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Identifiers

PMID: 10329618
DOI: 10.1093/emboj/18.10.2707
PMCID: PMC1171353

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.PMID 10329618Read ↗

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