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Article

Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae.

Genes & development - 15 Jun 2004

Pan Jing, Chen Rey-Huei

Abstract excerpt

The spindle checkpoint arrests cells at the metaphase-to-anaphase transition until all chromosomes have properly attached to the mitotic spindle. Checkpoint proteins Mad2p and Mad3p/BubR1p bind and inhibit Cdc20p, an activator for the anaphase-promoting complex (APC). We find that upon spindle checkpoint activation by microtubule inhibitors benomyl or nocodazole, wild-type Saccharomyces cerevisiae contains less...

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Source

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Identifiers

PMID: 15198982
DOI: 10.1101/gad.1184204
PMCID: PMC423194

Genes

APC
CDC20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae.PMID 15198982Read ↗

Dominant alleles of Saccharomyces cerevisiae CDC20 reveal its role in promoting anaphase.Semantic proximity Read ↗

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.Semantic proximity Read ↗

Budding yeast Cdc20: a target of the spindle checkpoint.Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase.Semantic proximity Read ↗

Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation.Semantic proximity Read ↗

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