Article
Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma.
Journal of neuro-oncology - 1 May 2007
Malmer Beatrice Susanne, Feychting Maria, Lönn Stefan, Lindström Sara, Grönberg Henrik, Ahlbom Anders, Schwartzbaum Judy, Auvinen Anssi, Collatz-Christensen Helle, Johansen Christoffer, Kiuru Anne, Mudie Nadejda, Salminen Tiina, Schoemaker Minouk J, Swerdlow Anthony J, Henriksson Roger
Abstract excerpt
BACKGROUND: P53 and ATM are central checkpoint genes involved in the repair of DNA damage after ionising irradiation, which has been associated with risk of brain tumours. Therefore, we tested the hypothesis that polymorphisms and haplotypes in p53 and ATM could be associated with glioma and meningioma risk. MATERIAL AND METHODS: Six hundred and eighty glioma cases (298 glioblastoma (GBM)), 503 meningioma cases,...
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