Article
Landscape of Germline Genetic Variants in AGT, MGMT, and TP53 in Mexican Adult Patients with Astrocytoma.
Cellular and molecular neurobiology - 1 Aug 2021
Carlos-Escalante José Alberto, Gómez-Flores-Ramos Liliana, Bian Xiaopeng, Perdomo-Pantoja Alexander, de Andrade Kelvin César, Mejía-Pérez Sonia Iliana, Cacho-Díaz Bernardo, González-Barrios Rodrigo, Reynoso-Noverón Nancy, Soto-Reyes Ernesto, Sánchez-Correa Thalía Estefanía, Guerra-Calderas Lissania, Yan Chunhua, Chen Qingrong, Castro-Hernández Clementina, Vidal-Millán Silvia, Taja-Chayeb Lucía, Gutiérrez Olga, Álvarez-Gómez Rosa María, Gómez-Amador Juan Luis, Ostrosky-Wegman Patricia, Mohar-Betancourt Alejandro, Herrera-Montalvo Luis Alonso, Corona Teresa, Meerzaman Daoud, Wegman-Ostrosky Talia
Abstract excerpt
Astrocytoma is the most common type of primary brain tumor. The risk factors for astrocytoma are poorly understood; however, germline genetic variants account for 25% of the risk of developing gliomas. In this study, we assessed the risk of astrocytoma associated with variants in AGT, known by its role in angiogenesis, TP53, a well-known tumor suppressor and the DNA repair gene MGMT in a Mexican population. A...
Topics
- Adult
- Angiotensinogen
- Astrocytoma
- Brain Neoplasms
- Case-Control Studies
- Cohort Studies
- DNA Modification Methylases