Article
Comprehensive analysis of DNA repair gene variants and risk of meningioma.
Journal of the National Cancer Institute - 20 Feb 2008
Bethke Lara, Murray Anne, Webb Emily, Schoemaker Minouk, Muir Kenneth, McKinney Patricia, Hepworth Sarah, Dimitropoulou Polyxeni, Lophatananon Artitaya, Feychting Maria, Lönn Stefan, Ahlbom Anders, Malmer Beatrice, Henriksson Roger, Auvinen Anssi, Kiuru Anne, Salminen Tiina, Johansen Christoffer, Christensen Helle Collatz, Kosteljanetz Michael, Swerdlow Anthony, Houlston Richard
Abstract excerpt
BACKGROUND: Meningiomas account for up to 37% of all primary brain tumors. Genetic susceptibility to meningioma is well established, with the risk among relatives of meningioma patients being approximately threefold higher than that in the general population. A relationship between risk of meningioma and exposure to ionizing radiation is also well known and led us to examine whether variants in DNA repair genes...
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