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Article

Association of PARP1 SNP (rs1136410) with Brain Tumor Risk: Insights from Khyber Pakhtunkhwa.

Asian Pacific journal of cancer prevention : APJCP - 1 Jun 2026

Gul Sajjad, Ali Sajid, Nouman Muhammad, Rehman Adnan Ur, Khan Sana, Hussain Sumbal, Afzal Shaista, Ali Hamid, Ashraf Muhammad, Anwar Naveed

Abstract excerpt

BACKGROUND: Brain tumors are among the most complex and life-threatening malignancies, with limited understanding of their genetic etiology. Poly (ADP-ribose) polymerase 1 (PARP1) plays a critical role in DNA repair. The single nucleotide polymorphism (SNP) rs1136410 (A>G) in PARP1, which results in a Val762Ala substitution, has been suggested to alter PARP1 enzymatic activity and potentially influence tumor...

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Biomarkers, Tumor
Brain Neoplasms
Case-Control Studies
Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poly (ADP-Ribose) Polymerase-1

Source

Identifiers

PMID: 42345145
DOI: 10.31557/APJCP.2026.27.6.1997

Genes

PARP1

Variants

rs1136410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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