Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis.

PloS one - 1 Jan 2014

Vogel Lotte K, Sæbø Mona, Høyer Helle, Kopp Tine Iskov, Vogel Ulla, Godiksen Sine, Frenzel Franz B, Hamfjord Julian, Bowitz-Lothe Inger Marie, Johnson Egil, Kure Elin H, Andersen Vibeke

Abstract excerpt

BACKGROUND & AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. METHODS: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Colorectal Neoplasms

Share to Cyclooxygenase 2

Share to Intestinal Mucosa

Share to Intestines

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 25166592
DOI: 10.1371/journal.pone.0105254
PMCID: PMC4148233

Genes

PTGS2
AGT

Variants

rs689466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis.PMID 25166592Read ↗

Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.Semantic proximity Read ↗

Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer.Semantic proximity Read ↗

Cyclooxygenase-2 (COX2) gene polymorphisms and the risk of sporadic colorectal cancer and polyps among Jordanian population.Semantic proximity Read ↗

COX-2 polymorphisms in patients with familial adenomatous polyposis.Semantic proximity Read ↗

The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis.Semantic proximity Read ↗

Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population.Semantic proximity Read ↗

PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population.Semantic proximity Read ↗

Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.Semantic proximity Read ↗

COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention.Semantic proximity Read ↗

Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma.Semantic proximity Read ↗

Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.Semantic proximity Read ↗

Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.